Showing posts with label fluoxetine. Show all posts
Showing posts with label fluoxetine. Show all posts

Monday, April 25, 2011

Why Fluoride is NOT good for our kids

http://www.fluoridealert.org/health/brain/

Key Findings - Fluoride & the Brain:

1) Fluoride's ability to damage the brain represents one of the most active areas of research on fluoride toxicity today.

2) The research on fluoride and the brain has been fueled by 18 human studies from China, India, Iran, and Mexico finding elevated levels of fluoride exposure to be associated with IQ deficits in children. Fluoride's impact on IQ is exacerbated among children with low-iodine exposure.

3) The impact of fluoride on children's IQ has been documented even after controlling for children's lead exposure, iodine exposure, parental education and income status, and other known factors that might impact the results (Rocha-Amador 2007; Xiang 2003 a,b).

4) In addition to IQ studies, 3 studies (Yu 1996; Du 1992; Han 1989) have found that fluoride accumulates in the brain of the fetus, causing damage to cells and neurotransmitters and 1 study (Li 2004) has found a correlation between exposure to fluoride during fetal development and behavioral deficits among neonates.

5) Several recent studies have found that even adult exposures to fluoride may result in central nervous system disturbances, particularly among industrial workers.

5) The findings of neurological effects in fluoride-exposed humans is consistent with, and strengthened by, recent findings from over 40 animal studies published since 1992. As with the studies on humans, the studies on animals have reported an impairment in learning and memory processes among the fluoride-treated groups.

6) The animal studies have also documented considerable evidence of direct toxic effects of fluoride on brain tissue, even at levels as low as 1 ppm fluoride in water (Varner 1998). These effects include:

-- reduction in nicotinic acetylcholine receptors;
-- reduction in lipid content;
-- impaired anti-oxidant defense systems;
-- damage to the hippocampus;
-- damage to the purkinje cells;
-- increased uptake of aluminum;
-- formation of beta-amyloid plaques (the classic brain abnormality in Alzheimer's disease);
-- exacerbation of lesions induced by iodine deficiency; and
-- accumulation of fluoride in the pineal gland.

Articles of Interest - Fluoride & the Brain:

* NEW: FAN's Translation Project: Chinese Research on Fluoride's Neurotoxicity
* New Evidence on Fluoride & the Developing Brain - FAN, January 17, 2008
* Excerpts from NRC Report - FAN, March 28, 2006
* Yet more research on fluoride and the brain - FAN Science Watch June 25, 2004
* Fluoride's effects on the brain - Ellen Connett, Director, Fluoride Action Network Pesticide Project, April 19, 2004
* Fluoride Linked to Low IQ, Studies Show - Fluoride Action Network August 25, 2003
* In Harm's Way: Toxic Threats to Child Development Greater Boston Physicians for Social Responsibility May 2000
* On the Neurotoxicity of Fluoride Phyllis Mullenix, Ph.D., September 14, 1998
* Fluoride & The Brain: An Interview with Dr. Phyllis Mullenix Interview by Paul Connett, PhD, October 18, 1997
* Fluoride & the Pineal Gland IFIN Bulletin, March 2001
* Rat Studies Link Brain Cell Damage With Aluminum and Fluoride in Water Wall Street Journal October 28, 1992

Ways to Remove Fluoride from Water
  • Reverse Osmosis Filtration
    This is used to purify several types of bottled water (not all), so some bottled waters are unfluoridated.
Products:
AquaCera Quick Change Reverse Osmosis System $600

Sierra Reverse Osmosis Drinking Water Filter System, by New Wave Enviro $250

5 Stage Reverse Osmosis Water Filter System with Storage Tank $155

Watts WP5-50 Premier Five-Stage Manifold Reverse Osmosis Water Treatment System $200

  • Activated Alumina Defluoridation Filter
    These filters are used in locales where fluorosis is prevalent. They are relatively expensive (lowest price I saw was $30/filter) and require frequent replacement, but do offer an option for home water filtration.
  • Distillation Filtration
    There are commercially available distillation filters that can be purchased to remove fluoride from water. On a related note: When looking at bottled water, keep in mind that 'distilled water' does not imply that a product is suitable for drinking water and other undesirable impurities may be present.
These Do NOT Remove Fluoride
  • Brita, Pur, and most other filters.
    Some websites about fluoride removal state otherwise, but I checked the product descriptions on the companies' websites to confirm that fluoride is left in the water.
  • Boiling Water
    This will concentrate the fluoride rather than reduce it.
  • Freezing Water
    Freezing water does not affect the concentration of fluoride.

___

Fluoride: The New Lead

http://www.laleva.org/eng/2010/12/fluoride_the_new_lead.html>
originally from
OpEdNews
December 12, 2010
By Dr Stuart Jeanne Bramhall


It took decades to "prove" that even low-level lead exposure caused mental
retardation and behavioral problems in children. In 1973 when I graduated from
medical school, there was a mountain of compelling evidence of the terrible
things lead in paint and auto exhaust was doing to kids. However under pressure
from corporate interests (the companies who put lead in gasoline and paint), the
medical establishment still officially proclaimed that at "subclinical levels,"
lead was totally safe.

Fortunately Nixon's newly created Environmental Protection Agency stood up to
the corporate elite in 1973. Taking the emphatic position that even low-level
lead exposure was posing a direct threat to public health, they ultimately
forced the US auto industry (in 1975) to install catalytic converters in cars,
to enable them to run on unleaded fuel. The use of lead-based paint in homes was
banned in 1978.

A Regulatory Agency that Refuses to Regulate
Unfortunately, despite overwhelming evidence that fluoride has the same effect as lead in lab animals and children, In 2010 the EPA has virtually ceased to perform any meaningful regulatory function. Which is most unfortunate, given that many US municipalities still put fluoride in the public drinking water (which can't be removed by simple filtration and is found in many brands of bottled water).
It boggles the mind that communities across the US continue to mass medicate their residents without their consent -" with a substance that has never been approved by the Food and Drug Administration (it's actually unpurified toxic waste from the agricultural phosphate industry and contains heavy metals and radionucleotides). Not only does this constitute a major civil rights infringement, but it poses far more danger to human health than the TSA full body scanners at airports.

Established Link to Hip Fractures, Bone Cancer and Liver Cancer
The evidence linking water fluoridation to hip fractures, bone cancer, and liver cancer is unequivocal. In 2006, after three years of study, doctors, chemists, toxicologists and other researchers appointed by the National Research Council concluded the preponderance of evidence showed that water fluoridation was causing an increase in hip fractures and bone and liver cancer, in addition to its neurotoxic effects in children (see http://www.fluoridealert.org/nrc-review.htm). They also found strong evidence that it was contributing to an epidemic of hypothyroidism, infertility and arthritis in Americans (1/3 of Americans suffer from arthritis). However they felt more research was needed in these areas. Nevertheless they felt the established health risks were so serious, they strongly recommended all water fluoridation be stopped while additional studies were completed. There is an excellent 98 minute interview with some of these scientists at http://blip.tv/file/2223981/.

Fraudulent Science
One area they didn't explore, which BBC investigative journalist Christopher Bryson covers in his 2004 book Fluoride Deception, is the systematic way that corporate interests have "doctored" fluoride research. One common practice was to selectively publish research favorable to fluoride, while simultaneously firing and blacklisting scientists whose studies showed otherwise. Scientists who research medical problems related to genetically modified foods face the same problem -" their work is suppressed, while they themselves are fired and blacklisted. Thanks to Bryson others, who obtained dozens of secret documents regarding water fluoridation via the Freedom of Information Act, the full extent of this massive fraud is finally in the public domain.

The Decision to Fluoridate the Public Water Supply
As Christopher Bryson outlines in Fluoride Deception, the decision to deliberately dose US municipal water systems with a potent industrial toxin was basically a corporate scam dreamed up by Alcoa, General Motors, and DuPont in the thirties and forties - to stem a tide of lawsuits related to death and injuries from toxic fluoride pollution (by convincing the public that fluoride is good for you). Alcoa was involved because fluoride is an extremely toxic pollutant produced by aluminum smelting. GM and DuPont were involved because GM held the patent on fluoride-based Freon (DuPont manufactured it), a common refrigerant which has since been banned. Unsurprisingly the same corporate researchers who "proved" that fluoride was safe also tried to convince the American public that lead, asbestos, smoking and plutonium were safe.

Fluoride Declared Hazardous Waste in 1930
According to Bryson, scientists have known for decades that fluoride is extremely toxic - in fairly low doses - to all mammals, including humans. In fact the FDA first declared fluoride a serious health hazard in the early thirties. The result was scores of lawsuits by aluminum workers crippled and killed by fluoride poisoning and by farmers near aluminum plants, whose livestock were killed by fluoride emissions.
Public Relations: Cheaper than Pollution Controls
Rather than encouraging his employer to institute pollution controls, an Alcoa researcher named Francis Frary decided a better solution was to alter public perception of fluoride - by convincing Americans that it improved dental health. Frary approached Mellon Institute researcher Gerald Cox, who performed a single study in rats (who don't really suffer much tooth decay) in 1937 and "proved" that fluoride strengthened teeth. Around the same time, the same Gerald Cox also "proved" that mesothelioma (a rare lung cancer that killed Steve McQueen) wasn't caused by asbestos.
Back then the concept of peer reviewed research was unknown, and the American Medical Association declared that the "case for fluoride" was proved. It's clear that corporate largesse (from General Motors) was instrumental in getting the American Dental Association on board with water fluoridation. Whether the AMA also benefited from corporate generosity remains unclear.
Kettering Bribes the American Dental Association
Frary and Cox were soon joined in their little scam by Charles Kettering, who was both GM's research director and a Freon magnate. Kettering was the first to approach the American Dental Association with their proposal to fluoridate public water systems. He also began funding many of their activities and got appointed to their three member Advisory Committee on Research in Dental Caries.
Meanwhile GM and DuPont hired scientist Robert Kehoe to perform safety studies on both fluoride and tetra ethyl lead, a gasoline additive co-manufactured by the two companies. And for obvious reasons, Kehoe declared both lead and fluoride safe at "low levels."
Enter the Atomic Energy Commission and the Father of Public Relations
In the 1940s these corporate researchers were joined in their scheme to promote water fluoridation by Dr Harold Hodge the chief toxicologist of the Manhattan Project (the secret US project to build and atomic bomb).Hodge became involved in "Project F" because large amounts of fluoride are used in the construction of the atomic bomb, and the Atomic Energy Commission was concerned about heading off a flood of lawsuits from Manhattan Project scientists exposed to toxic levels of fluoride. This was the same Harold Hodge who, in his role as chief Manhattan Project toxicologist, experimented on unsuspecting patients at Rochester 's Strong Memorial Hospital , by injecting them with plutonium.
Nevertheless the most prominent villain in this sordid history of lies and secrecy was the infamous father of the public relations industry (i.e. the sophisticated use of propaganda to sway public opinion) Edward Bernays. There was massive public opposition to water fluoridation from the very beginning -" led mainly by doctors who were well aware of fluoride's toxicity. Bernays' answer was to enlist even more prominent doctors to declare it safe, starting with famous baby doctor Benjamin Spock.

A Systematic Corporate Cover-Up
As Christopher Bryson outlines clearly in the Fluoride Deception, the whole notion of fluoride being safe and good for teeth is based on decades of corporations paying researchers to produce the scientific results they want -" and burying research and firing and blacklisting scientists whose studies show otherwise.
As Bryson points out, it was actually mass fluoride poisoning that kick-started the environmental movement, following an air pollution disaster in 1948 that killed 20 people and sickened hundreds more. A temperature inversion and air pollution from a US Steel factory is blamed for the Donora ( Pennsylvania ) Death Fog. However owing to extreme pressure from the steel and aluminum industry, public health authorities colluded in a systematic cover-up of the autopsy results - which revealed that the victims had toxic fluoride levels in their blood (see http://www.fluoridation.com/donora.htm).
GM fluoride researcher Charles Kettering also deliberately suppressed the results of his own lab's 1962 studies demonstrating that fluoride produced lung damage in beagles.
This sordid history also includes deliberate smear campaigns against extremely reputable doctors and scientists who published research and clinical findings showing that water fluoridation has adverse health effects:
* Dr. George Waldbott - a world famous doctor who first identified penicillin allergy and the link between smoking and emphysema. Waldbott published numerous double blind studies in the fifties showing that fluoride is harmful to human health. The result was a massive corporate smear campaign that destroyed his reputation by marginalizing and demonizing him.
* Dr William Marcus - a senior EPA toxicologist in the Office of Water, fired in 1992 for attempting to publicize studies revealing that fluoride causes bone and liver cancer (see http://www.gaia-health.com/articles251/000293-epa-scientists-oppose-fluoridation.shtml). In 1994 Marcus won lawsuit against the federal government and was reinstated. While the EPA still refuses to ban water fluoridation, the unions representing EPA scientists have called for a moratorium (see http://www.nteu280.org/Issues/Fluoride/Press%20Release.%20Fluoride.htm).
* Dr Phyllis Mullinix - research toxicologist hired by Forsyth Dental Institute to study the effect of fluoride on the brain. In the mid-nineties, Mullinex was first fired and then blacklisted in the when she published research showing that fluoride produces memory and behavior problems in children.
Where Does Fluoride Comes From?
Although fluoride is added to municipal water systems as a "drug" - that allegedly improves dental health - it has never been approved by the FDA. In fact most communities source their fluoride from the phosphate fertilizer industry, as hydrofluorosilicic acid. This is an extremely toxic, hazardous waste, and the EPA requires phosphate manufacturers to capture it via "wet scrubbers" in their chimneys (to prevent toxic fluoride gas from being released into the air). The resulting liquid is then loaded, unpurified, into tanker trucks and sold to cities to be added to their public water supply. In addition to fluoride, it also contains a number of heavy metals and radionucleotides (radioactive elements - mainly uranium-238, uranium-234, thorium-230, radium-226, radon-222, lead-210, and polonium-210).

Why 98% of European Communities Have Banned Water Fluoridation
Austria, Belgium, Denmark, Finland, France, Germany, Iceland, Italy, Luxembourg, Netherlands, Norway, and Sweden all ban water fluoridation - for five main reasons:

1. The preponderance of independent research reveals that fluoridation (at levels as low as 0.7 parts per million) increases the risk of hip fracture, liver and bone cancer and lowered IQ in children - as well as being strongly implicated in an American epidemic of hypothyroidism, arthritis and infertility. The concentration used in most American cities is 1.0 parts per million.

2. It's an absolute violation of medical ethics for a doctor to prescribe a drug, in unlimited doses (people who eat processed foods or drink large amounts of fruit juice, soft drinks and tea get much higher doses), to someone they have never met, without informed consent or ongoing monitoring of their response.

3. The World Health Organization has compared communities with and without water fluoridation and found the rate of cavities is no higher in communities who don't fluoridate their water (and doesn't increase when they remove it). In fact communities who don't fluoridate seem to have somewhat better dental health. Individuals who accumulate toxic levels of fluoride (known as dental fluorisis) actually have weaker tooth enamel. (Americans have the highest rate of dental fluorosis in the world - 33% overall and 41% in teenagers between 12-15). Research has consistently shown that fluoride only reduces tooth decay when it's applied directly to the teeth - drinking fluoride weakens the enamel.

4. All medical and dental authorities worldwide agree that infants are at risk of fluoride toxicity if their formula is made up with fluoridated water (see http://www.fluoridealert.org/infant-warning.pdf). This poses a real health hazard to low income families, who can't afford the luxury of distilled water.

5. The vast majority of Europeans don't want fluoride in their water when the risks are explained to them. (The administration of any drug requires informed consent - and they don't consent.)
Thus far 60 US communities (as a result of citizen activism) have ended fluoridation of their public water system. For support in getting the fluoride out of your water go to http://www.fluoridealert.org/ There is also an excellent interview with Bryson regarding his book at http://www.fluoridealert.org/bryson.htm.
Author's Website: www.stuartbramhall.com
______

http://articles.mercola.com/sites/articles/archive/2010/11/13/cdc-and-ada-now-advise-to-avoid-using-fluoride.aspx

CDC and ADA Now Advise to Avoid Using Fluoride
from Dr. Mercola | November 13 2010 |

A new study in the Journal of the American Dental Association finds once again that, contrary to what most people have been told, fluoride is actually bad for teeth.

Exposure to high levels of fluoride results in a condition known as fluorosis, in which tooth enamel becomes discolored. The condition can eventually lead to badly damaged teeth. The new study found that fluoride intake during a child's first few years of life is significantly associated with fluorosis, and warned against using fluoridated water in infant formula.

The Centers for Disease Control and Prevention (CDC) is of a similar opinion. According to their website:

"Recent evidence suggests that mixing powdered or liquid infant formula concentrate with fluoridated water on a regular basis may increase the chance of a child developing ... enamel fluorosis."

Sources:
Journal of the American Dental Association October 14, 2010; 141(10):1190-1201
CDC May 28, 2010


Dr. Mercola's Comments:

It was 2007 when the American Dental Association (ADA) first warned that parents of infants younger than a year old "should consider using water that has no or low levels of fluoride" when mixing baby formula, due to concerns about fluorosis.

Now the Journal of the American Dental Association has published a study that found increased fluorosis risk among infants who were fed infant formula reconstituted with fluoride-containing water, as well as used fluoridated toothpastes.

The authors noted:

"Results suggest that prevalence of mild dental fluorosis could be reduced by avoiding ingestion of large quantities of fluoride from reconstituted powdered concentrate infant formula and fluoridated dentifrice."

The U.S. Centers for Disease Control and Prevention (CDC) has also followed suit, warning on their Community Water Fluoridation page that mixing powdered or liquid infant formula concentrate with fluoridated water on a regular basis may increase the chance of a child developing enamel fluorosis.

They also state:

"In children younger than 8 years of age, combined fluoride exposure from all sources—water, food, toothpaste, mouth rinse, or other products—contributes to enamel fluorosis."

This is as far as the CDC warnings go, however, and they continue to state that water fluoridation is safe -- and dental fluorosis is only a "cosmetic" problem. In reality, neither of these assertions is true.

Dental Fluorosis is a Sign of Excessive Fluoride Intake


Dental fluorosis results in white and brown spots on your teeth. It is only caused by fluoride -- typically due to ingesting too much fluoride during your developing years, from birth to about 8 years of age. According to the CDC, about one-third of U.S. children aged 12 to 15 years have very mild to mild forms of enamel fluorosis on their teeth.

Promoters of fluoridation say that these markings are "just cosmetic," but it can also be an indication that the rest of your body, such as your bones and the rest of your organs, including your brain, has been exposed to too much fluoride also.

As Dr. Paul Connett, a chemist specializing in environmental chemistry, explained in our recent interview:

"We know that 32 percent of American children have been overexposed to fluoride because you have this telltale sign of dental fluorosis, which in its mildest form is little white specs. But when it gets more serious, it affects more of the surface of your teeth and it becomes colored; yellow, brown and orange mottling of the teeth …

The teeth are the window to the bones. If you've seen the damage to the teeth, what damage can you not see?"

In other words, if fluoride is having a detrimental, visual effect on the surface of your teeth, you can be virtually guaranteed that it's also damaging something else inside your body, such as your bones.

Bone is living tissue that is constantly being replaced through cellular turnover. Bone building is a finely balanced, complicated process. Fluoride has been known to disrupt this process ever since the 1930s.

Why it's Dangerous to Swallow Fluoride

The United States is one of only eight countries in the entire developed world that fluoridates more than 50 percent of its water supply. It is added under the guise that it helps prevent and control tooth decay …

This is in spite of the fact that there never been any demonstrated difference in tooth decay between countries with fluoridated and non-fluoridated water, and no difference between states that have a high- or low percentage of their water fluoridated.

Even promoters of fluoridation concede that the major benefits are topical; fluoride works from the outside of the tooth, not from inside of your body, so why swallow it?

The fluoride added to your drinking water is in fact a chemical waste product! It is NOT something you should use as a supplement to your diet.

There are plenty of studies showing the dangers of fluoride to your health, such as:

* Increases lead absorption
* Disrupts synthesis of collagen
* Hyperactivity and/or lethargy
* Muscle disorders
* Brain damage, and lowered IQ
* Arthritis
* Dementia
* Bone fractures
* Lowers thyroid function
* Bone cancer (osteosarcoma)
* Inactivates 62 enzymes
* Inhibits formation of antibodies
* Genetic damage and cell death
* Increases tumor and cancer rate
* Disrupts immune system
* Damages sperm and increases infertility

As far as tooth decay is concerned, this is not caused by lack of fluoride.

Tooth decay is caused by acids in your mouth, typically created from sugar being metabolized by bacteria (Streptococcus mutans), and as you may already know, the number one source of calories in the United States is high fructose corn syrup.

The acid produced then attacks your enamel. Eventually the bacteria can get into the dentine, at which point tooth decay sets in. So there are far better options for decreasing tooth decay than using a topical or ingested poison, with a chief one being minimizing your intake of sugary foods and eating a healthful diet.

You typically don't find dental caries in more primitive societies that do not consume vast amounts of sugar like in the United States.

Make Sure Your Children are Not Exposed to Fluoride

One of dentist Bill Osmunson's main concerns is water fluoridation for infants. The ADA and the CDC now both recommend that infants NOT receive fluoridated water for drinking, nor for making their formula, as fluoridated water contains 250 times more fluoride than mother's milk.

"We shouldn't fluoridate water and harm our most vulnerable," Dr. Osmunson says.

It is my strong belief and recommendation to avoid giving your children fluoridated water.

Unfortunately, the only way to ensure your water is pure enough to drink is by installing ahigh quality water filtration system in your house, such as a reverse osmosis filter that can filter out much of the fluoride and other dangerous water contaminants like disinfection byproducts (DBPs).

Remember that most bottled water also typically contains fluoride, even though it's not stated on the label, and whatever you do, avoid using "nursery water," which is fluoridated water sold specifically for infants.

Fluoride in your drinking water is one more reason why breastfeeding your infant is so essential. Nature has kept breast milk virtually fluoride-free for a reason.

If you are unable to breastfeed and are instead using formula, make sure the water you use is fluoride-free. Again, for now the best way you can provide pure, fluoride-free water to your family is by using a reverse osmosis filter, which you can install in your home.

Even better, if you are unable to breastfeed use this recipe to make homemade infant formula using raw milk and no water at all.

Keep in mind also that if you are a pregnant woman it is equally important for your water to be fluoride-free, as this chemical can harm your developing fetus.

The Ultimate Solution is to Get Fluoride Out of Tap Water

Even though the ADA and the CDC have issued warnings that parents not use fluoridated tap water to make infant formula, neither of them has openly informed the public!

So there are millions of parents out there using tap water to make up formula, oblivious of the fact that the agencies that promote fluoridation in this country have issued a specific warning against using fluoridated water for this purpose.

Not only that, but by fluoridating the municipal water supply you doom many low-income families to fail to protect their young children from this dangerous drug, even if they have this information, as they simply don't have the resources to install a reverse osmosis system.

This is why the only real solution is to stop the archaic practice of water fluoridation in the United States.

The Fluoride Action Network is an absolutely phenomenal resource for further education, and they're doing much to pressure the US government for change. We will be working together to devise a complete game plan to tackle this issue head on. Once we reach the tipping point, which may be as little as 5 percent of the population, we will be able to reverse the policies of water fluoridation.

Our strategy will begin with addressing Canada, because 60 percent of Canada is already un-fluoridated. If we can get the rest of Canada to stop fluoridating their water, we believe the U.S. will be forced to follow.

You can visit www.FluorideAlert.org for the most recent updates and progress, as well as tips on how you can get involved and take action in this important cause.

In addition, I highly recommend getting a copy of Dr. Connett's new book, The Case Against Fluoride, for more information on the bad science and political agendas that got this toxic chemical in our drinking water and is, at least for now, keeping it there.

Prozac is a fluorinated drug called "fluoxetine"

In animals chronic administration of fluoxetine resulted in a decrease in both T4 and T3 levels. The authors reported that the major effect of the drug “seems to be stimulation of TSH synthesis and release via the inhibition of T4-mediated thyroid-pituitary feedback” (Golstein et al, 1983).

In rat brain, fluoxetine has also been shown to interfere with local T3 metabolism (Eravci et al, 2000; Baumgartner et al, 1994).... In the 1930s is was first observed that all fluoride compounds, organic and inorganic ones, inhibit thyroid hormones. Prof. Kurt Kraft exposed tadpoles(bufo vulgaris, rana temporaria) to fluoride compounds including sodium fluoride, fluorotyrosine and fluorobenzoic acid (Kraft, 1937). Litzka’s experiments (1937) showed that the thyroid inhibition was due to activity in the liver (similar to PTU). Numerous fluoride compounds were used subsequently as the first line of treatment for hyperthyroidism in various countries, for several decades.... Fluoxetine is a known inhibitor of multiple P450 isoenzymes, thus interfering with the metabolism of other substances (Thompson et al, 1997; 2003).

... Fluoxetine has been shown to cause severe liver dysfunction such as hepatitis (Cai et al, 1999; Johnston & Wheeler, 1997; Mars et al, 1991; Friedenberg & Rothstein, 1996).

Fluoxetine has also been shown to cause secondary hyperthyroidism - originating from pituitary dysfunction (Martinez & Ortiz, 1999)

. http://www.poisonfluoride.com/pfpc/html/prozac.html

...........

Fluorine is also found in mind-affecting drugs like Prozac and the "date rape" drug Rohypnol. Click here for a more complete list of drugs containing fluorine. :http://www.just-think-it.com/no-f.htm


http://www.thehealthvine.net/index.php?option=com_content&view=article&id=36&Itemid=58

Organofluorine compounds.

Today the chemical industry is making more and more organofluorine compounds which are used as solvents, propellants, refrigerants, (e.g the CFCs or chlorinated fluorcarbons), plastics (e.g. teflon), pharmaceuticals (e.g. prozac) and pesticides. The problem with these organofluorine compounds along with their organochlorine cousins, is that they produce very dangerous byproducts when burned, are fat soluble, are highly persistent in the environment, resist detoxification in our bodies, frequently interfere with hormonal signals, accumulate in our fat and are transferred to the fetus during pregnancy.

So just like the organochlorine compounds, which were often exploited for their "apparent" non-toxicity and their persistence, it is their very persistence which is coming back to haunt us as well as their more subtle toxicity.

In this connection, of particular concern are the perfluorinated octanyl compounds or PFOs e.g. PFOA (perfluorinated octanoic acid). These substances comprise a chain of 8 carbons completely saturated with fluorine at all positions (this is what the prefix "per" means) except the terminal group. These substances are being found throughout the environment and in human tissues throughout the world (See a recent discussion of this topic entitled "Fluorine Persists" by Stephen Ritter in C &EN, June 14, 2004). The PFOs are thought to be strong endocrine disrupters (i.e. they interfere with various hormonal signals in both animals and humans). One example is perfluorinated octanyl sulfonate (PFOS) which was manufactured by 3M corporation (skotchguard) but which it voluntarily ceased manufacturing in May, 2000.

The fluorine atom is very small and so when pharmaceutical companies develop a therapeutically active molecule (i.e. a drug) they will often put fluorine into the molecule in place of an hydrogen atom and usually at a place where the molecule is normally metabolized because the C-F bond is much more stable to enzymatic attack than a C-H bond. They do this in order to increase the time the body takes to metabolize the drug and thus enable the prescription of smaller doses. This is where we get into a highly contentious issue among those opposed to fluoridation. Some have assumed that the fluorine present in these drugs (such as prozac) represent another source of fluoride in our daily lives. However, this would only be the case if the drug is actually metabolized at the C-F bond. However, for most pharmaceuticals, this is unlikely. Other sites in the molecule are more likely to be attacked and the excreted water soluble metabolites are thus likely to still contain the fluorine atom covalently attached to the molecule. However, this is not always the case as has been demonstrated for some of the fluorinated anesthetics and propellants. To resolve the issue for drugs like prozac we need to have confirmation from the drug companies (and/or the FDA) that based upon mass balance studies all the fluorine can be accounted for in the excreted water soluble metabolites for the drug in question.

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Tuesday, April 5, 2011

Prozac Cures Lazy Eye!

Scroll to bolded text.

By Jonah Lehrer
July 6, 2008

PROZAC IS ONE of the most successful drugs of all time. Since its introduction as an antidepressant more than 20 years ago, Prozac has been prescribed to more than 54 million people around the world, and prevented untold amounts of suffering.
But the success of Prozac hasn't simply transformed the treatment of depression: it has also transformed the science of depression. For decades, researchers struggled to identify the underlying cause of depression, and patients were forced to endure a series of ineffective treatments. But then came Prozac. Like many other antidepressants, Prozac increases the brain's supply of serotonin, a neurotransmitter. The drug's effectiveness inspired an elegant theory, known as the chemical hypothesis: Sadness is simply a lack of chemical happiness. The little blue pills cheer us up because they give the brain what it has been missing.

There's only one problem with this theory of depression: it's almost certainly wrong, or at the very least woefully incomplete. Experiments have since shown that lowering people's serotonin levels does not make them depressed, nor does it worsen their symptoms if they are already depressed.

In recent years, scientists have developed a novel theory of what falters in the depressed brain. Instead of seeing the disease as the result of a chemical imbalance, these researchers argue that the brain's cells are shrinking and dying. This theory has gained momentum in the past few months, with the publication of several high profile scientific papers. The effectiveness of Prozac, these scientists say, has little to do with the amount of serotonin in the brain. Rather, the drug works because it helps heal our neurons, allowing them to grow and thrive again.

In this sense, Prozac is simply a bottled version of other activities that have a similar effect, such as physical exercise. They aren't happy pills, but healing pills.

These discoveries are causing scientists to fundamentally reimagine depression. While the mental illness is often defined in terms of its emotional symptoms - this led a generation of researchers to search for the chemicals, like serotonin, that might trigger such distorted moods - researchers are now focusing on more systematic changes in the depressed brain.

"The best way to think about depression is as a mild neurodegenerative disorder," says Ronald Duman, a professor of psychiatry and pharmacology at Yale. "Your brain cells atrophy, just like in other diseases [such as Alzheimer's and Parkinson's]. The only difference with depression is that it's reversible. The brain can recover."

Given the prevalence of depression - more than 16 percent of people will suffer from a major depressive episode at some point in their lives - a more accurate scientific understanding of the disease is of immense value. In fact, this research is already being used to develop more effective treatments for the mental illness, some of which are currently in clinical trials.

The progress exemplifies an important feature of modern medicine, which is the transition from a symptom-based understanding of a disease - depression is an illness of unrelenting sadness - to a more detailed biological understanding, in which the disease is categorized and treated based on its specific anatomical underpinnings.

In the 19th century, the "fever" was a common medical illness. Of course, doctors now realize that a fever is merely a common symptom of many different diseases, from the flu to leukemia.
Likewise, when Richard Nixon declared a "War on Cancer" in 1971, scientists largely defined cancer in terms of its most tangible characteristic: uncontrolled growth leading to a tumor. As a result, every cancer was treated with the same blunt tools. Over time, of course, scientists have discovered that cancer is not a single disease with a single biological cause. Breast cancer, for instance, can be triggered by a wide variety of genes and environmental risk factors. Because doctors can look beyond the superficial similarities of the symptoms - all tumors are not created equal - they are able to tailor their treatments to the specific disease.

Neuroscience is only beginning to catch up. Thanks to a variety of new experimental tools, such as brain scanners and DNA microarrays, researchers are now refining their understanding of mental illness. In many instances, this means recategorizing disorders, (like DS as a neurobiological disorder) so that patients are no longer diagnosed solely in terms of their most obvious symptoms.
"We used to think there was only one kind of anemia," says Arturas Petronis, a scientist at the University of Toronto who investigates the underlying causes of schizophrenia. "But now we know there are at least 15 different kinds. We'll likely learn the same thing about many mental illnesses."
. . .
One of the first cracks in the chemical hypothesis of depression came from a phenomenon known as the "Prozac lag." Antidepressants increase the amount of serotonin in the brain within hours, but the beneficial effects are not usually felt for weeks.

This led neuroscientists to wonder if something besides serotonin might be responsible. Duman, for instance, began to study a class of proteins known as trophic factors, which help neurons grow and survive. Trophe is Greek for nourishment; what sunlight and water do for trees, trophic factors do for brain cells. Numerous studies had shown that chronic stress damages the brain by suppressing the release of trophic factors. In a series of influential papers published earlier this decade, Duman demonstrated that the same destructive hallmark is seen in depression, so that our neurons are deprived of what they need.

"The mental illness occurs when these stress mechanisms in the brain spiral out of control," he says.

Once that happens, the brain begins to shut itself down, suppressing all but the most essential upkeep. Not only do neurons stop growing, but the brain seems to stop creating new cells. A 2003 study, led by Columbia University neuroscientist Rene Hen, found that when the birth of new brain cells was blocked with low doses of radiation in "depressed" rats, antidepressants stopped working.

A recent study by Italian researchers, published in the journal Science, helps to reveal another mechanism by which antidepressants reverse the damage of depression. The scientists were interested in seeing if fluoxetine, the active ingredient of Prozac, could increase the potential of brain cells in the adult rat. They studied animals with severe cases of "lazy eye," a condition characterized by poor vision in one eye due to underdevelopment of the visual cortex. The scientists showed that fluoxetine gave brain cells the ability to take on new roles and form new connections, which erased the symptoms of the disorder. (Jett had nystagmus, which is an eye flutter and occasional eye crossing. Although western medicine says that nystagmus is incurable, his nystagmus is gone [maybe from acupressure and Traditional Chinese Medicine?]. He also had occasional eye crossing which rarely occurs now on Prozac.)

"The drug appears to make brain cells quite young," says Jose Vettencourt, a lead author. The scientists are currently repeating the experiment with humans, raising the possibility that fluoxetine will soon be used to treat lazy eye and related conditions.

"Even five years ago, this would have seemed like a very strange idea," Vettencourt says.
Duman's lab has demonstrated, in a paper published earlier this year, that physical exercise seems to stimulate the same regenerative pathways. Mice given access to running wheels not only showed reduced anxiety and stress, but also increased levels of the same trophic factors activated by antidepressants. When the activity of these trophic factors was blocked, the benefits of exercise disappeared. The mice stayed stressed, even when they were allowed to run on their wheel.

It is jarring to think of depression in terms of atrophied brain cells, rather than an altered emotional state. It is called "depression," after all. Yet these scientists argue that the name conceals the fundamental nature of the illness, in which the building blocks of the brain - neurons - start to crumble. This leads, over time, to the shrinking of certain brain structures, like the hippocampus, which the brain needs to function normally.

In fact, many scientists are now paying increased attention to the frequently neglected symptoms of people suffering from depression, which include problems with learning and memory and sensory deficits for smell and taste. (Common problems in autism and DS. Young autistic children are often treated with SSRI's to reestablish these pathways). Other researchers are studying the ways in which depression interferes with basic bodily processes, such as sleeping, sex drive, and weight control. Like the paralyzing sadness, which remains the most obvious manifestation of the mental illness, these symptoms are also byproducts of a brain that's literally withering away.
"Depression is caused by problems with the most fundamental thing the brain does, which is process information," says Eero Castren, a neuroscientist at the University of Helsinki. "It's much more than just an inability to experience pleasure."

This new scientific understanding of depression also offers a new way to think about the role of drugs in recovery. While antidepressants help brain cells recover their vigor and form new connections, Castren says that patients must still work to cement these connections in place, perhaps with therapy. He compares antidepressants with anabolic steroids, which increase muscle mass only when subjects also go to the gym.
"If you just sit on your couch, then steroids aren't going to be very effective," he says. "Antidepressants are the same way: if you want the drug to work for you, then you have to work for the drug."
Jonah Lehrer is an editor at large at Seed magazine and the author of "Proust Was a Neuroscientist." He is a regular contributor to Ideas.
© Copyright 2008 Globe Newspaper Company.

Related Posts

CMF Protocol: Prozac
Vitamin C Plays Important Role in Eye & Brain Function
Prozac & Vision Problems in DS
Improve Your Child's Vision
My TV/Video Strategy
Some TV is Good for Our Kids!
Get Your Own Neurodevelopmentalist
Video games as a possible therapy to lazy eye?
Crawling: Important for Eye Development

Wednesday, March 30, 2011

CMF Protocol: Prozac

The uncomfortable part of the Changing Minds Foundation protocol is the use of Prozac. Let's address these fears one at a time so you can make the most informed decision possible. Your child is different from every other child so you really need to weigh the pros and cons depending on your particular situation. I discuss my struggles with my decision to use Prozac for Jett in several posts. In this post, however, I try to just give you the studies and some notes for the big picture on Prozac as well as details on Jett's use of it and then how he is now that he is off of it. I wish we did not have to make these tough decisions, but it is part of our job as caregivers for our loved one.

Why do some use Prozac for T21?


Early Pharmacotherapy restores Neurogenesis and Cognitive Performance in the Ts65Dn Mouse Model for Down Syndrome
Conclusions
...The current study shows that it is possible to increase cell proliferation in numerous regions of the postnatal brain in a mouse model for DS [they gave a mouse DS]. We have used fluoxetine [generic version of Prozac] to stimulate neurogenesis [the birth of neurons], because it is an antidepressant widely used by adults and prescribed in children and adolescents (Boylan et al., 2007) and it has no patent aversive effects on somatic development (Bairy et al., 2007; Einarson et al., 2009). Treatment during the early postnatal period restored neurogenesis and led to the restoration of the total number of neurons in the dentate gyrus. This effect was accompanied by the full recovery of a cognitive task. The transfer of these data to the human condition would imply that a simple pharmacological treatment during the earliest phases of development might be exploited to improve neurogenesis and, possibly, mental retardation in infants with DS.
Full article here:
http://www.jneurosci.org/content/30/26/8769.long

Great article about how they discovered that Prozac helps with neurogenesis:
http://seedmagazine.com/content/article/the_reinvention_of_the_self/

Excerpt:

In December 2000, Duman’s lab published a paper in the Journal of Neuroscience demonstrating that antidepressants increased neurogenesis in the adult rat brain. In fact, the two most effective treatments they looked at—electroconvulsive therapy and fluoxetine, the chemical name for Prozac—increased neurogenesis in the hippocampus by 75% and 50%, respectively. Subsequent studies did this by increasing the exact same molecules, especially trophic factors, that are suppressed by stress.
Duman was surprised by his own data. Fluoxetine, after all, had been invented by accident. (It was originally studied as an antihistamine.) “The idea that Prozac triggers all these different trophic factors that ultimately lead to increased neurogenesis is just totally serendipitous,” Duman says. “Pure luck.”
-------
Disinhibition Plus Instruction Improve Brain Plasticity
Excerpt:
They found that giving the mice fluoxetine allowed the neurons to bypass the retraction phase and go right to the constructive phase. But this constructive remodeling had to occur at the same time as visual stimulation — an instructive clue — from the functioning eye.
“We think this finding could have clinical relevance,” Nedivi said. For example, during stroke rehabilitation, providing instructive activities with fluoxetine might accelerate a brain region’s adoption of a function previously performed by a damaged region.
Full article:
http://www.vadvert.co.uk/health/11835-disinhibition-plus-instruction-improve-brain-plasticity.html
Prozac also treat vision issues in DS. See this post: Prozac Cures Lazy Eye!

When I took Jett off Prozac

On Prozac, I didn't see a sudden difference in Jett although his crossing eyes had slowly cleared up. But, once I took Jett off Prozac for 2 weeks, I saw the major areas that Prozac was helping him.
Off Prozac he was experiencing:
1) Constipation. Does not go at all... I just wait 7 days and make him go... (He went one small drop last night and was in terrible pain.)
2) His eyes are crossing so much that he turns his head all over the place to try to see better.
3) I can't leave him to play independently anymore because he goes and finds a sock or some string to wave in front of his face and goes, "Eeeeeeeeeeeeee," until I redirect him. This may be because of the constipation?
4) I'm the only one he wants. No one else can hold him except sometimes my husband. So I'm back to "wearing him" in a wrap to get anything done & prevent stimming. (Have you ever tried to shape dough into hot dog buns while holding a baby?) But, while holding him, he attempts to stim with the strings on my pants and the straps on my shirt.

On P, he would have fine bowel movements for 2-3 weeks out of the month. His eyes rarely crossed. The stimming was almost completely gone! I didn't really have to worry about it anymore. He'd just play happily and occupy himself.

Update on taking Jett off Prozac 

I got so freaked about Jett's negative reaction to being off Prozac, that I put him back on for a while until I could figure out what to do. So when I took him off again, I added in some tryptophan to help ease the transition and help him produce his own serotonin again and I lowered the dose slowly rather than cold turkey. This worked very well.
I didn't like the fact that Prozac was masking, rather than curing Jett's eye issues and wanted to address them directly. I couldn't do this if I couldn't see the problem. The same with the stimming issues. Without Prozac, I've been able to use vision therapy and address the sensory issues that was causing the stimming. Now his eyes only misalign when he is very tired or looking at something very close up. The developmental vision therapist is very pleased with Jett's eye improvement. As for the stimming, that took some time and effort as well. Now he, again, only stims when he is tired. It makes me immediately realize that I need to put him to down for a nap or for the night. Concerning the constipation, increasing his vitamin C intake and properly addressing his thyroid has eventually eliminated this problem as well.
There were also many supplements that Prozac interfered with that I wanted to try. So that was another motivation to take Jett off.

Positive effects I've seen with Jett OFF Prozac

Once I got past the first bout of the negative effects of taking him off, I was able to realize how much better off he was NOT on Prozac. I realized that his speech actually stalled the entire time and even regressed a bit on it. Once he was off, his speech just skyrocketed again. Fortunately, before Prozac, his speech was stellar so even with the stalling, he wasn't too far behind and quickly progressed. So, all in all, giving Prozac was something that I needed to try, but now I really feel that he's better off without it. Not knowing the true and long term side effects just didn't sit well with me and kept me up at night.

Possible drug interactions

 
L-tryptophan (found in Nutrivene DS formula & night time formula) 
5-HTPL-dopa
anorexiants
anticonvulsants
antidepressants
anxiolytics
calcium channel blockers
cyproheptadine
lithium salts
drugs of abuse


Reports have suggested that when taken in the form of a supplement, L-tryptophan can interact adversely with fluoxetine. Typical symptoms include nausea and vomiting, agitation, anxiety and restlessness, headache, dizziness and increased perspiration. Individuals taking fluoxetine should avoid the use of L-tryptophan supplements without consulting the prescribing physician and/or a nutritionally trained healthcare professional. Apparently this response has never been elicited when fluoxetine has been combined with a protein-rich diet containing significant levels of L-tryptophan.4

Avoid supplements containing tryptophan or 5-HTP.
The adverse reactions include the "serotonin syndrome", cardiovascular complications, extrapyramidal side effects such as akathisia, dyskinesias, and parkinsonian-like syndromes and an apparently increased risk of suicidality. Fluoxetine-induced mania and hypomania, seizures and sexual disorders are evaluated along with minor symptoms of allergic reactions, stuttering, hematological changes, psoriasis, and inappropriate secretion of the antidiuretic hormone. The major fluoxetine-drug interactions involve the amino acids L-dopa and L-tryptophan, anorexiants, anticonvulsants, antidepressants, anxiolytics, calcium channel blockers, cyproheptadine, lithium salts, and drugs of abuse.

Andi's Note:
Naturally occurring tryptophan is important to eat when taking Prozac since it promotes the body's ability to produce serotonin. Food sources of tryptophan include red meat, dairy products, nuts, seeds, bananas, tuna, shellfish, quinoa and turkey. Shrimp, Crimini mushrooms, turkey and mustard greens are among the largest sources. See: WHFoods: tryptophan for complete details.
Vitamin B6 is necessary for the conversion of tryptophan to both niacin and serotonin.


Possible side effects
This video shows a calm, intelligent description of the possible dangers: http://www.ihealthtube.com/aspx/viewvideo.aspx?v=b3750aff0ff9aed9

My reaction to the video:
Permanently alters the brain: YES, that is our goal with Prozac. Even after our kids stop taking it, the new dendrites will still be there.Addictive: As he explained, IF the patient is NOT properly nourished with foods that promote serotonin production (such as naturally occurring tryptophan), addiction can occur under certain circumstances. He also explained that this probably won't happen if doses are kept low, as ours is. People looking to SSRIs to help with depression may have a greater chance of experiencing this. Our kids don't take it for depression. Therefore, there is no need to look to raise the dose (except as their weight increases.)
Zoloft/Paxil are TERRIBLY addictive because, as he said, it's out of the body in a couple of days so the patient comes crashing down since their bodies don't have enough time to adjust to the lack of serotonin. The withdrawals are scary and can last for a week. (I know because I experienced this.)
Prozac stays in the body a long time afterward so the patient doesn't feel that crash. (I know because I experienced this.)
______

Prozac May Stunt Growing Bones

Please note that low-dose fluoxetine hydrochloride (5 mg/kg)-treated (LOW); and high-dose fluoxetine hydrochloride (20 mg/kg)-treated (HIGH). Fluoxetine hydrochloride (Sigma-Aldrich, Inc.) was chosen as the SSRI for use because it has been shown to have a favorable risk-benefit profile in children and adolescents
The CMF protocol suggest 1 mg up to 20 mg, depending on age. vs. the 20 mg for every 2.2 lbs that they used in the following study:

Related Health News

By E.J. Mundell
HealthDay Reporter

THURSDAY, Nov. 11 (HealthDayNews) -- The success of Prozac in easing depression in children may come at the price of impaired bone growth, suggests a study in mice.

Researchers say cellular mechanisms important to bone growth may shut down in the presence of the drug, hindering healthy skeletal development. Growing mice exposed to Prozac for even a few weeks averaged 9.4 percent less bone formation in their thighbones compared to unexposed mice, the researchers report.

"This is a mouse study, however, and I wouldn't take people off Prozac based on just this study," stressed lead researcher Stuart Warden, an assistant professor of physical therapy at Indiana University School of Medicine. "Still, as a researcher, I would start to think about planning trials to address this in a clinical population."

In a statement, representatives from Eli Lilly & Co., the makers of Prozac, said "the findings warrant consideration, and should be placed in the context of the established record of safety and efficacy of fluoxetine [Prozac] in humans."

The study is published in the November issue of Endocrinology.

Prozac is just one of a family of antidepressants called selective serotonin reuptake inhibitors (SSRIs), which also include Celexa, Paxil and Zoloft. All of these drugs interact with nerve cells to increase production of the neurotransmitter serotonin, which is low in people with depression.

However, researchers recently discovered that 5-HTT -- a serotonin transporter molecule that is key to this process -- is also found in cells responsible for building and maintaining bone.

"If you have serotonin around these cells and these cells have receptors, serotonin actually influences the activity of those bone cells," Warden explained.

Using the same logic, his team theorized that serotonin-targeted SSRI drugs such as Prozac might also affect bone development.

To find out, they first examined bone growth in mice genetically engineered to lack functioning 5-HTT serotonin transporters in bone cells. A shutdown of this transporter "would be similar to being on lifelong Prozac, Zoloft or any other SSRI," Warden explained.

Compared to normal mice, these animals had bones that were between 6 percent to 13 percent narrower on average. Their bones were also weaker and less dense.

The researchers then shifted their focus to short-term Prozac exposure, giving young, growing mice daily injections of either low- or high-dose Prozac, or placebo, for four weeks.

"When we gave Prozac to really young mice that were still rapidly growing, it reduced the amount of bone they gained," Warden said. "It reduced their bone growth -- not how long the bones were, but how wide, and how thick."

Compared to unexposed mice, young mice exposed to relatively high doses of Prozac displayed a 6 percent and 9.4 percent reduction in bone formation in their spines and thighbones, respectively, according to the researchers.

Warden stressed that the study focused on Prozac because it is the sole SSRI currently granted U.S. Food and Drug Administration approval for use in children. He believes other SSRIs would have similar effects on bone.

"There's no reason to believe Prozac is unique here," Warden said.

For their part, representatives at Lilly said the study is far from conclusive. They point out, for example, that mice exposed to Prozac were somewhat less active than unexposed mice, offering an alternate explanation as to differences in bone mass.

They also defended Prozac's safety record. "Lilly has sponsored five clinical trials of Prozac in children, and all have been published in independent, peer-reviewed journals," the company said in a statement. "The safety and efficacy of Prozac is well-studied, well-documented, and well-established."

But Warden believes that larger clinical trials are warranted. He pointed to studies in adults that linked long-term SSRI use with an increased risk for hip fracture, as well as reduced bone mineral density in the neck and spine.

Prozac has already faced intense public scrutiny recently, following reports suggesting that it and other SSRIs might raise suicide risks in children.

"The main point of our study is not to induce panic in people on these drugs, but to highlight that further research is necessary," Warden said. "We need to have independent studies looking at these drugs, so things aren't brushed under the carpet."

More information

For the latest on the risks and benefits of antidepressant use by children, go to the U.S. Food and Drug Administration.

SOURCES: Stuart Warden, Ph.D., assistant professor, physical therapy,
Indiana University School of Medicine, Indianapolis; statement, Eli
Lilly & Co., Indianapolis; November 2004 Endocrinology
Copyright ©2004 HealthDay. All Rights Reserved.
This is a story from HealthDay, a service of ScoutNews, LLC.
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Antidepressants Linked to Thicker Arteries

Antidepressant use has been linked to thicker arteries, possibly contributing to the risk of heart disease and stroke, in a study of twin veterans. The data is being presented Tuesday, April 5 at the American College of Cardiology meeting in New Orleans.

Depression can heighten the risk for heart disease, but the effect of antidepressant use revealed by the study is separate and independent from depression itself, says first author Amit Shah, MD, a cardiology fellow at Emory University School of Medicine. The data suggest that antidepressants may combine with depression for a negative effect on blood vessels, he says. Shah is a researcher working with Viola Vaccarino, MD, PhD, chair of the Department of Epidemiology at Emory’s Rollins School of Public Health.

The study included 513 middle-aged male twins who both served in the U.S. military during the Vietnam War. Twins are genetically the same but may be different when it comes to other risk factors such as diet, smoking and exercise, so studying them is a good way to distill out the effects of genetics, Shah says.

Researchers measured carotid intima-media thickness – the thickness of the lining of the main arteries in the neck -- by ultrasound. Among the 59 pairs of twins where only one brother took antidepressants, the one taking the drugs tended to have higher carotid intima-media thickness (IMT), even when standard heart disease risk factors were taken into account. The effect was seen both in twins with or without a previous heart attack or stroke. A higher level of depressive symptoms was associated with higher IMT only in those taking antidepressants.

“One of the strongest and best-studied factors that thickens someone’s arteries is age, and that happens at around 10 microns per year,” Shah says. “In our study, users of antidepressants see an average 40 micron increase in IMT, so their carotid arteries are in effect four years older.”

Antidepressants’ effects on blood vessels may come from changes in serotonin, a chemical that helps some brain cells communicate but also functions outside the brain, Shah says. The most commonly prescribed antidepressants are selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine (Prozac), which increase the level of serotonin in the brain. Other types of antidepressants also affect serotonin levels, and antidepressants can act on other multi-functional brain chemicals such as norepinephrine.

In the study, researchers saw higher carotid IMT in both participants who used SSRIs (60 percent of those who took antidepressants) and those who used other types of antidepressants.

Most of the serotonin in the body is found outside the brain, especially in the intestines, Shah notes. In addition, serotonin is stored by platelets, the cells that promote blood clotting, and is released when they bind to a clot. However, serotonin’s effects on blood vessels are complex and act in multiple ways. It can either constrict or relax blood vessels, depending on whether the vessels are damaged or not.

“I think we have to keep an open mind about the effects of antidepressants on neurochemicals like serotonin in places outside the brain, such as the vasculature. The body often compensates over time for drugs’ immediate effects,” Shah says. “Antidepressants have a clinical benefit that has been established, so nobody taking these medications should stop based only on these results. This isn’t the kind of study where we can know cause and effect, let alone mechanism, and we need to see whether this holds up in other population groups.”

In addition to Prozac, Jett also takes his curcumin everyday, which helps support his heart. His last heart check up showed a perfectly healthy heart, in size, shape and function. He will have another cardio evaluation in June. Will update then.
June's evaluation revealed a perfect heart, but the cardio sees signs of possible pulmonary hypertension. I'm looking into treatment and causes. I'm considering adding CoQ10 for support.


###

The Robert W. Woodruff Health Sciences Center of Emory University is an academic health science and service center focused on missions of teaching, research, health care and public service.


Possible Side Effect: Tardive Dyskinesia
Tardive dyskinesia is a movement disorder caused by long-term use of certain medications called neuroleptic drugs, along with some other drugs that increase the brain's sensitivity to the neurotransmitter dopamine. It is characterized by uncontrolled facial movements such as protruding tongue, chewing or sucking motions and making faces.
Tardive dyskinesia is a very serious side effect of antipsychotic medications in particular, and patients taking such drugs should know what to watch for. Drugs that can cause tardive dyskinesia are mainly antipsychotic medications and include:
  • Abilify (Aripiprazole)
  • Clozaril (Clozapine) (may also treat the condition)
  • Geodon (Ziprasidone)
  • Haldol (Haloperidol)
  • Loxitane / Loxapac (Loxapine)
  • Mellaril (Thioridazine)
  • Navane (Thiothixine)
  • Orap (Pimozide)
  • Piportil (Pipotiazine)
  • Prolixin / Modecate (Fluphenazine)
  • Risperdal (Risperidone)
  • Serentil (Mesoridazine)
  • Seroquel (Quetiapine)
  • Stelazine (Trifluoperazine)
  • Thorazine (Chlorpromazine)
  • Trilafon (Perphenazine)
  • Zyprexa (Olanzapine)
Some of the non-neuroleptic drugs that may also cause tardive dyskinesia are:
  • Asendin (Amoxapine)
  • Cocaine and other street drugs
  • Elavil (Amitriptyline)
  • Lithium
  • Nardil (Phenelzine)
  • Prozac (Fluoxetine)
  • Sinequan (Doxepine)
  • Tofranil (Imipramine)
  • Zoloft (Sertraline)
Ironically, the neuroleptic drugs are dopamine antagonists, meaning they block dopamine receptors on nerve cells. However, over time this can cause the brain to compensate by creating more dopamine receptors and making them more sensitive, leading to serious side effects.

Symptoms of Tardive Dyskinesia
 
Tardive dyskinesia is characterized by repetitive, involuntary, purposeless movements such as:

  • Fine, worm-like movements of the tongue
  • Lip smacking
  • Chewing or sucking movements
  • Grimacing (making faces)
  • Puckering or pursing the lips
  • Tongue protrusion
  • Rapid eye blinking
There may also be uncontrolled movements of the arms, legs and body. According to an article at Wikipedia, "Impaired movements of the fingers may appear as though the patient is playing an invisible guitar or piano."

Prevention, Treatment and Outlook
Prescribing physicians should attempt prevention by prescribing the lowest effective dose of these medications for the shortest possible time. After a diagnosis of tardive dyskinesia, decreasing dosage or discontinuing the problem drug(s) may solve the problem, or it may cause symptoms to worsen. If they do get worse, they may eventually go away, or they may continue indefinitely. Thus, it is important to get an early diagnosis if you suspect you or a loved one is exhibiting symptoms of this disorder.

A number of medications have been used to try to control the symptoms of tardive dyskinesia, including Clozaril (clozapine), Botox (botulinum toxin), benzodiazepines such as Klonopin (clonazepam), and several others. Treatment is not always successful.

Andi's Note: It's theorized that increasing dopamine intake may help to offset this side effect. Non-pharmaceutical ways to increase dopamine are:

NADH (an activated form of niacin..B3)
Mucana Pruriens....an herb
Phenylalanine
Tyrosine

Jett takes 100mg of tyrosine every morning.
I do know of some children who have this side effect from Prozac's use. One child felt like a "purring kitten" in her mother's arms. Her movements stopped after discontinuing Prozac. Another child had a lot of the other movements such as teeth grinding and lip smacking. This child used Prozac for 5 years.

References
Brasic, J.R. (2006). Tardive Dyskinesia. Retrieved July 30, 2006 from http://www.emedicine.com/neuro/topic362.htm.
National Institute of Neurological Disorders and Stroke. (2006). NINDS Tardive Dyskinesia Information Page. Retrieved July 30, 2006 from http://www.ninds.nih.gov/disorders/tardive/tardive.htm.
Periut, P. (2005). Tardive Dystonia. Retrieved July 30, 2006 from http://www.emedicine.com/med/topic620.htm.
Wikipedia. (2006). Tardive Dyskinesia. Retrieved July 30, 2006 from http://en.wikipedia.org/wiki/Tardive_dyskinesia.
Source: http://bipolar.about.com/od/sideeffectslibrary/f/tardivedyskines.htm
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Weight gain in infants breastfed by mothers who take fluoxetine.

Chambers CD, Anderson PO, Thomas RG, Dick LM, Felix RJ, Johnson KA, Jones KL.

Departments of Pediatrics, University of California, San Diego, California 92103, USA. chchambers@ucsd.edu
OBJECTIVE: Despite the manufacturer's recommendation that fluoxetine not be used by women while breastfeeding, many women choose to do so. There is little information available in the literature to suggest that this practice is or is not safe. The purpose of this study was to examine weight gain in infants who are breastfed by mothers who take fluoxetine, compared with weight gain in infants who are breastfed by mothers who do not take any psychotherapeutic medication. A secondary goal was to assess the frequency of reported side effects in infants who are breastfed by mothers who take fluoxetine. METHODOLOGY: A retrospective cohort study design was used. Subjects were identified from an ongoing pregnancy outcome study conducted through the California Teratogen Information Service and Clinical Research Program. A total of 64 women were interviewed who had taken fluoxetine during a pregnancy between the 1989 and 1997; 26 of these women breastfed their infants and continued to take the medication, and 38 breastfed their infants but did not take the medication. Postnatal weight gain was taken from pediatric records, and the frequency of side effects was measured by maternal response to the interview questionnaire. RESULTS: Using linear regression analysis, the infants who were breastfed by mothers taking fluoxetine demonstrated a growth curve significantly below that of infants who were breastfed by mothers who did not take the drug. The average deficit in measurements taken between 2 weeks and 6 months of age was 392 g (95% confidence interval: -5, -780). Using a repeated measures analysis of covariance for those infants with more than one postnatal weight measurement available, the difference between the two groups was similar, approximately 1.2 standard deviations (P =.005). In response to interview questions regarding side effects, no mother who breastfed her infant while taking fluoxetine reported any unusual symptoms that could be attributed to the medication. CONCLUSIONS: These data do not suggest that women who breastfeed while taking fluoxetine are likely to note unusual behavior in their infants that they consider related to use of the medication. However, although there was no excess of infants in the fluoxetine group with postnatal weight measurements >2 standard deviations below the mean, these data indicate that breastfeeding while taking fluoxetine is associated with reduced growth that may be of clinical importance in situations in which infant weight gain is already of concern.

PMID: 10545587 [PubMed - indexed for MEDLINE]

Andi's note: Weight gain has been a constant battle for Jett. The first month and a half, he was considered Failure to Thrive, off and on, but I was able to get him up to the 50% in time for his heart surgery at 6 months.
Jett has gained only two pounds and lost one pound in the 10 months since heart surgery (age 6 to 16 months). He's been on Prozac from age 10-16 months. I haven't seen a change in his appetite, but it certainly hasn't improved on Prozac! His BMI indicates that he is underweight for his height at 13%. On the typical growth chart, his weight is well below 0%, on the DS growth chart, his weight is below 10%. I feed him full fat foods including butter, avocado and coconut oil. He still is mostly breastfed, but I offer him solid food throughout the day. He enjoys eating whatever food I eat, but just doesn't eat much of it. He is full of energy and sleeps well.


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